pink pigmented

METPO:1003027 · CLASS · REVIEWED

A pigmentation phenotype in which microbial colonies or cells appear pink due to accumulation of pink or rose carotenoid pigments.

Pink pigmentation carotenoid mechanism

Evidence-backed causal sketch linking pink microbial pigmentation to carotenoid biosynthesis, conjugated carotenoid pigments, and visible pink color.

Pink pigmentation carotenoid mechanism Interactive directed graph showing evidence-backed causal relationships for pink pigmented.

Edge evidence

  • isoprenoid precursors feed into carotenoid biosynthesis

    Isoprenoid precursors provide substrate for carotenoid production.

    • DOI:10.1016/j.gene.2004.11.038 isoprenoid precursor biosynthesis Supports isoprenoid precursor biosynthesis as an upstream step in eubacterial carotenoid pathways.
  • Crt enzymes catalyzes carotenoid biosynthesis biolink:catalyzes

    Crt enzymes catalyze reactions in carotenoid biosynthesis.

    • DOI:10.1080/1040841X.2025.2526423 crt genes ... reactions they catalyze Supports Crt enzymes as pathway catalysts.
  • carotenoid biosynthesis produces pink carotenoids METPO:2000202

    Carotenoid biosynthesis can produce pink bacterial pigments.

    • DOI:10.1080/1040841X.2025.2526423 pink ... pigmentation in bacteria Supports carotenoids as one source of pink bacterial pigmentation.
  • pink carotenoids causes visible pink color biolink:causes

    Pink carotenoids cause visible pink pigmentation.

    • DOI:10.1080/1040841X.2025.2526423 responsible for the red, pink, orange, and yellow pigmentation Supports the color-producing role of carotenoid pigments.
  • visible pink color manifests as pink pigmented METPO:2007400

    Visible pink color manifests the pink-pigmented phenotype.

    • DOI:10.1080/1040841X.2025.2526423 pink ... pigmentation in bacteria Supports trait-level pink pigmentation from bacterial carotenoids.
  • lycopene precursor of pink carotenoids

    Lycopene is the central precursor converted into colored downstream carotenoid pigments.

    • DOI:10.3390/biology12101346 Sandmann review: lycopene is the central carotenoid intermediate from which colored carotenoid pigments are formed via crt pathway reactions.
  • carotenoid biosynthesis feeds from lycopene

    Carotenoid biosynthesis proceeds through lycopene toward colored carotenoid products.

    • DOI:10.3390/biology12101346 crtI/phytoene desaturase generates lycopene as a committed colored-carotenoid intermediate in the biosynthetic pathway.
  • Crt enzymes part of photosynthesis gene cluster biolink:part_of

    crt carotenoid genes are part of photosynthesis gene clusters in phototrophic bacteria.

    • DOI:10.3390/biology12101346 "the genes of the carotenoid pathways are part of photosynthesis gene clusters" (Sandmann 2023).
  • photosynthesis gene cluster contributes to visible pink color RO:0002326

    Carotenoid genes embedded in photosynthesis gene clusters contribute to visible pigmentation.

    • DOI:10.3390/biology12101346 "The pigmentation of purple bacteria is caused by a combination of bacteriochlorophylls and carotenoids" with crt genes in PGCs.
  • oxygen upregulates crtI-crtB operon

    Oxygen availability upregulates the carotenoid biosynthetic operon, an environmental regulator of pigment output.

    • DOI:10.3390/biology12101346 "oxygen up-regulates the crtI-crtB operon" (Sandmann 2023), making oxygen a causal environmental regulator of pigmentation.
  • crtI-crtB operon catalyzes carotenoid biosynthesis biolink:catalyzes

    The crtI-crtB operon encodes enzymes carrying out carotenoid biosynthetic reactions.

    • DOI:10.3390/biology12101346 crtB (phytoene synthase) and crtI (phytoene desaturase) catalyze committed steps producing colored carotenoids.

Provenance

Source
METPO (2025-11-25)
Definition source
DOI:10.1080/1040841X.2025.2526423

Parent traits (1)

Synonyms (1)

  • Pigment_pink RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1003027 [-4.184, -3.258, -1.095, +0.518, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · CURATED_WITH_LITERATURE · codex

    Added DOI-backed definition and causal graph for isoprenoid precursors, Crt enzymes, carotenoid biosynthesis, pink carotenoids, and visible pink color.

  3. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1).

  4. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:catalyzes×1, biolink:causes×1).

  5. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007400×1).

  6. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0016117×1).

  7. · ENRICH_CAUSAL_GRAPH · claude

    Added 6 evidence-backed generic edges (4 new nodes) from the deep-research report.

  8. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 3 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:part_of×1, RO:0002326×1, biolink:catalyzes×1).

  9. · GROUND_CAUSAL_NODES · claude

    Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:15948×1, ENVO:01001495×1).