cream pigmented

Edge evidence

• low-level carotenoid biosynthesis produces low pigment accumulation METPO:2000202

  Limited carotenoid (or analogous) pigment biosynthesis produces low pigment accumulation.

  • DOI:10.1146/annurev.micro.62.081307.162844 bacterial carotenoid pigments Supports carotenoid biosynthesis as the source of bacterial pigmentation.
• low pigment accumulation yields pale cream coloration biolink:produces

  Low pigment density yields a pale, cream-colored optical phenotype.

  • DOI:10.1146/annurev.micro.62.081307.162844 bacterial carotenoid pigments Supports pigment density as the determinant of colony color intensity.
• pale cream coloration manifests as cream pigmented METPO:2007400

  Pale coloration manifests the cream-pigmented trait.

  • DOI:10.1146/annurev.micro.62.081307.162844 bacterial carotenoid pigments Supports the trait endpoint.
• carotenoid biosynthesis genes (crt locus) enables low-level carotenoid biosynthesis RO:0002327

  Core crt-locus enzymes are required for carotenoid biosynthesis; their activity sets pathway flux.

  • DOI:10.3390/pathogens12010086 Insertions mapped to crtE, crtI, crtB, crtYc, crtYd involved in synthesis of beta-carotene; disrupted mutants retained an off-white appearance.
• carotenoid biosynthesis gene disruption decreases low-level carotenoid biosynthesis RO:0002212

  Disruption or repression of core carotenoid-biosynthesis genes lowers carotenoid synthesis, leaving colonies pale/off-white.

  • DOI:10.3390/pathogens12010086 "Most of these mutants failed to develop pigmentation upon light treatment and retained an off-white appearance" with insertions in crt-pathway genes (broad but not universal across taxa).
• isoprenoid (MEP-pathway) precursor supply enables low-level carotenoid biosynthesis RO:0002327

  MEP-pathway isoprenoid precursor supply feeds carotenoid biosynthesis; reduced precursor supply lowers downstream carotenoid output.

  • DOI:10.3390/microorganisms9040670 Repression of the MEP-pathway gene ispG significantly lowered cellular carotenoid content; repression of MEP/carotenogenesis genes was expected to reduce pigmentation.