green pigmented

METPO:1003025 · CLASS · REVIEWED

A pigmentation phenotype in which microbial colonies or cultures appear green or blue-green due to pigments such as pyocyanin and pyoverdine.

Green pigmentation pyocyanin phenazine mechanism

Evidence-backed causal sketch linking green or blue-green microbial pigmentation to phenazine biosynthesis, phz genes, pyocyanin production, and visible green culture color.

Green pigmentation pyocyanin phenazine mechanism Interactive directed graph showing evidence-backed causal relationships for green pigmented.

Edge evidence

  • phz operons encodes phenazine biosynthesis biolink:encodes

    phz operons encode enzymes required for phenazine biosynthesis.

    • DOI:10.1186/s12934-023-02122-1 phenazine synthesis operons including phzA1, phzA2, phzS, and phzM Supports phz genes as pyocyanin/phenazine biosynthesis machinery.
  • phenazine biosynthesis produces pyocyanin METPO:2000202

    Phenazine biosynthesis produces pyocyanin.

    • DOI:10.1128/jb.138.3.846-852.1979 pyocyanine biosynthesis Supports pyocyanin production as a phenazine biosynthetic process.
  • pyocyanin causes visible green color biolink:causes

    Pyocyanin contributes blue-green visible pigmentation.

    • DOI:10.1186/s12934-023-02122-1 Pyocyanin is a blue phenazine pigment Supports pyocyanin as a visible blue/green pigment.
  • visible green color manifests as green pigmented METPO:2007400

    Visible green or blue-green culture color manifests the green-pigmented phenotype.

    • DOI:10.1186/s12934-023-02122-1 lead to the green colorization of the culture plate Supports trait-level green pigmentation from pyocyanin and related pigments in representative cultures.
  • chorismate precursor of phenazine-1-carboxylic acid (PCA)

    Chorismate is the shikimate-pathway precursor of phenazine-1-carboxylic acid.

    • DOI:10.1007/s11274-023-03548-w Biosynthesis of PYO and other phenazines proceeds from chorismate via the shikimate pathway.
  • phenazine-1-carboxylic acid (PCA) precursor of pyocyanin

    Phenazine-1-carboxylic acid is the core intermediate converted toward pyocyanin.

    • DOI:10.1007/s11274-023-03548-w PCA is the central phenazine from which pyocyanin is derived via the shikimate/phenazine pathway.
  • quorum sensing positively regulates pyocyanin

    Quorum sensing positively regulates pyocyanin production.

    • DOI:10.1186/s12934-023-02122-1 Quorum sensing controls pyocyanin synthesis; AHL and PQS autoinducers and LasR-LasI/RhlR-RhlI systems activate pyocyanin expression.
  • pyocyanin redox state and pH modifies visible green color

    Redox state and pH alter the apparent color of pyocyanin pigment.

    • DOI:10.1007/s11274-023-03548-w PYO exhibits blue-green color at neutral/alkaline pH, shifting to pink-red in acidic conditions; oxidized PYO is blue while reduced form is transparent.
  • pyoverdine NRPS enzymes (PvdL/PvdI/PvdJ/PvdD) participates in pyoverdine biosynthesis biolink:participates_in

    PvdL/PvdI/PvdJ/PvdD NRPS enzymes synthesize the pyoverdine peptide backbone.

    • DOI:10.3390/ijms25116013 The pyoverdine peptide backbone is synthesized by four NRPSs (PvdL, PvdI, PvdJ, PvdD).
  • iron-deficient conditions induces pyoverdine biosynthesis

    Iron-deficient conditions induce expression of pyoverdine biosynthetic enzymes.

    • DOI:10.3390/ijms25116013 Expression of the fluorescent (pyoverdine) enzymes was induced by iron-deficient growing conditions.
  • pyoverdine biosynthesis contributes to visible green color RO:0002326

    Pyoverdine, a yellow-green fluorescent pigment, contributes to green coloration alongside pyocyanin.

    • DOI:10.1186/s12934-023-02122-1 Blue (pyocyanin) and yellow (fluorescein/pyoverdine-like) pigments combine to produce green colorization of the culture.

Provenance

Source
METPO (2025-11-25)
Definition source
DOI:10.1186/s12934-023-02122-1

Parent traits (1)

Synonyms (1)

  • Pigment_green RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1003025 [-0.292, -0.545, -1.390, +0.056, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · CURATED_WITH_LITERATURE · codex

    Added DOI-backed definition and causal graph for phz operons, phenazine biosynthesis, pyocyanin, and visible green/blue-green color.

  3. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1).

  4. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:causes×1).

  5. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:encodes×1).

  6. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007400×1).

  7. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0002047×1).

  8. · ENRICH_CAUSAL_GRAPH · claude

    Added 7 evidence-backed generic edges (7 new nodes) from the deep-research report.

  9. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:participates_in×1, RO:0002326×1).

  10. · GROUND_CAUSAL_NODES · claude

    Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:29748×1, GO:0009372×1).