yellow pigmented

METPO:1003030 · CLASS · REVIEWED

A pigmentation phenotype in which microbial colonies or cells appear yellow due to production of yellow pigments such as carotenoids.

Yellow pigmentation carotenoid mechanism

Evidence-backed causal sketch linking yellow microbial pigmentation to crt-catalyzed carotenoid biosynthesis, yellow carotenoid accumulation, and visible yellow colony color.

Yellow pigmentation carotenoid mechanism Interactive directed graph showing evidence-backed causal relationships for yellow pigmented.

Edge evidence

  • Crt enzymes catalyzes carotenoid biosynthesis biolink:catalyzes

    Crt enzymes catalyze carotenoid biosynthetic reactions.

    • DOI:10.1080/1040841X.2025.2526423 crt genes ... reactions they catalyze Supports Crt enzymes as catalysts in bacterial carotenoid pathways.
  • carotenoid biosynthesis produces yellow carotenoids METPO:2000202

    Carotenoid biosynthesis produces yellow-pigment carotenoids in representative bacteria.

    • DOI:10.1080/1040841X.2025.2526423 yellow pigmentation in bacteria Supports carotenoids as one source of yellow pigmentation.
  • yellow carotenoids causes visible yellow color biolink:causes

    Yellow carotenoids cause visible yellow colony or cell color.

    • DOI:10.1016/j.tim.2010.07.007 Carotenoids are natural pigments Supports carotenoids as visible pigments in bacteria.
  • visible yellow color manifests as yellow pigmented METPO:2007400

    Visible yellow color manifests the yellow-pigmented phenotype.

    • DOI:10.1080/1040841X.2025.2526423 yellow pigmentation in bacteria Supports trait-level yellow pigmentation.
  • IPP/DMAPP precursor of geranylgeranyl diphosphate (GGPP)

    C5 precursors IPP/DMAPP are elongated to the C20 carotenoid precursor GGPP.

    • DOI:10.1038/s41598-024-58700-9 Carotenoid synthesis begins from the C5 isoprenoid precursors IPP and DMAPP, which are converted via chain elongation to the C20 precursor GGPP.
  • IdsA/CrtE (GGPP synthase) catalyzes geranylgeranyl diphosphate (GGPP) biolink:catalyzes

    IdsA/CrtE (GGPP synthase) catalyzes formation of GGPP from IPP and DMAPP.

    • DOI:10.1038/s41598-024-58700-9 IdsA, the major geranylgeranyl diphosphate synthase converting IPP and DMAPP to GGPP; GGPPS annotated CrtE/IdsA.
  • geranylgeranyl diphosphate (GGPP) precursor of lycopene

    Two GGPP molecules condense to form the C40 backbone lycopene.

    • DOI:10.1038/s41598-024-58700-9 Two GGPP molecules condense to form the C40 backbone lycopene.
  • CrtI (phytoene desaturase) enables lycopene biosynthesis RO:0002327

    CrtI (phytoene desaturase) enables lycopene biosynthesis.

    • DOI:10.3390/microorganisms12040803 Phytoene desaturase (CrtI) to produce lycopene.
  • lycopene biosynthesis produces lycopene METPO:2000202

    Lycopene biosynthesis produces lycopene.

    • DOI:10.3390/microorganisms12040803 Pathway proceeds through phytoene synthase (CrtB) and phytoene desaturase (CrtI) to produce lycopene.
  • CrtY (lycopene beta-cyclase) catalyzes conversion to beta-carotene

    CrtY (lycopene beta-cyclase) cyclizes lycopene to beta-carotene.

    • DOI:10.1038/s41598-024-58700-9 Lycopene is cyclized to beta-carotene by lycopene beta-cyclase (crtY).
  • beta-carotene causes or contributes to yellow pigmented

    beta-carotene is a canonical yellow/orange carotenoid that contributes to the yellow phenotype.

    • DOI:10.4014/jmb.2404.04018 beta-carotene serves as a colorant and is the classic yellow/orange carotenoid pigment.
  • flexirubin-type pigment contributes to yellow pigmented RO:0002326

    Flexirubin-type pigments produce yellow colony coloration, a carotenoid-independent yellow pigment route.

    • DOI:10.1038/s41467-024-54112-5 Flexirubin-type pigment-producing bacterium is yellow (or orange) in color; flexirubin is a known yellow pigment.
  • flexirubin-type pigment protects against reactive oxygen species damage

    Flexirubin protects against reactive oxygen species damage.

    • DOI:10.1038/s41467-024-54112-5 Flexirubin is known as a yellow pigment that effectively protects against reactive oxygen species damage.

Provenance

Source
METPO (2025-11-25)
Definition source
DOI:10.1080/1040841X.2025.2526423

Parent traits (1)

Synonyms (1)

  • Pigment_yellow RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1003030 [-3.392, -1.132, -2.360, -0.296, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · CURATED_WITH_LITERATURE · codex

    Added DOI-backed definition and causal graph for Crt enzymes, carotenoid biosynthesis, yellow carotenoids, and visible yellow color.

  3. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1).

  4. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:catalyzes×1, biolink:causes×1).

  5. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007400×1).

  6. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0016117×1).

  7. · ENRICH_CAUSAL_GRAPH · claude

    Added 9 evidence-backed generic edges (10 new nodes) from the deep-research report.

  8. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 4 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:catalyzes×1, RO:0002327×1, METPO:2000202×1, RO:0002326×1).

  9. · GROUND_CAUSAL_NODES · claude

    Grounded 3 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:15948×1, GO:1901177×1, CHEBI:17579×1).