orange pigmented

METPO:1003026 · CLASS · REVIEWED

A pigmentation phenotype in which microbial colonies or cells appear orange due to production and accumulation of orange pigments such as carotenoids.

Orange pigmentation carotenoid mechanism

Evidence-backed causal sketch linking orange microbial pigmentation to Crt enzymes, carotenoid biosynthesis, orange carotenoid accumulation, and visible orange color.

Orange pigmentation carotenoid mechanism Interactive directed graph showing evidence-backed causal relationships for orange pigmented.

Edge evidence

  • Crt enzymes catalyzes carotenoid biosynthesis biolink:catalyzes

    Crt enzymes catalyze bacterial carotenoid biosynthetic reactions.

    • DOI:10.1080/1040841X.2025.2526423 crt genes ... reactions they catalyze Supports Crt enzymes as catalysts in bacterial carotenoid pathways.
  • carotenoid biosynthesis produces orange carotenoids METPO:2000202

    Carotenoid biosynthesis produces orange pigments in representative bacteria.

    • DOI:10.1080/1040841X.2025.2526423 orange ... pigmentation in bacteria Supports carotenoid biosynthesis as a route to orange bacterial pigmentation.
  • carotenoid biosynthesis produces staphyloxanthin METPO:2000202

    The S. aureus carotenoid pathway produces staphyloxanthin.

    • DOI:10.1128/JB.147.3.900-913.1981 triterpenoid carotenoids possessing a C30 chain Supports staphyloxanthin-related C30 carotenoid pigments in S. aureus.
  • orange carotenoids causes visible orange color biolink:causes

    Orange carotenoids cause visible orange pigmentation.

    • DOI:10.1080/1040841X.2025.2526423 responsible for ... orange ... pigmentation Supports carotenoid pigments as determinants of orange color.
  • visible orange color manifests as orange pigmented METPO:2007400

    Visible orange color manifests the orange-pigmented phenotype.

    • DOI:10.1080/1040841X.2025.2526423 orange ... pigmentation in bacteria Supports the trait-level color assignment.
  • lycopene beta-cyclase (CrtY) converts lycopene

    CrtY lycopene beta-cyclase acts on lycopene as substrate.

    • DOI:10.3390/microorganisms11030614 lycopene is converted to beta-carotene by ring-forming lycopene cyclases; in bacteria the enzyme is crtY. Broad microbial applicability.
  • lycopene is converted to beta-carotene

    Lycopene cyclization yields orange beta-carotene.

    • DOI:10.3390/microorganisms11030614 lycopene is converted to beta-carotene by ring-forming lycopene cyclases (crtY). Broad microbial applicability.
  • beta-carotene hydroxylase (CrtZ) converts beta-carotene

    CrtZ beta-carotene hydroxylase acts on beta-carotene.

    • DOI:10.3390/microorganisms11030614 conversion of beta-carotene to zeaxanthin by crtZ. Strong general edge supporting orange/yellow branches.
  • beta-carotene is converted to zeaxanthin

    Hydroxylation of beta-carotene yields zeaxanthin.

    • DOI:10.3390/microorganisms11030614 crtZ encodes a beta-carotene hydroxylase converting beta-carotene to zeaxanthin. Strong general edge.
  • carotenoid ketolase (CrtW) contributes to ketocarotenoid biosynthesis RO:0002326

    CrtW ketolase drives ketocarotenoid (e.g., canthaxanthin/astaxanthin) formation.

    • DOI:10.3390/microorganisms11030614 ketolation by ketolases such as crtW yields ketocarotenoids (canthaxanthin/astaxanthin). Strong for the ketocarotenoid branch; orange-to-red hue.
  • carotenoid accumulation protects against oxidative stress / reactive oxygen species

    Accumulated carotenoids act as antioxidants neutralizing reactive oxygen species.

    • DOI:10.7759/cureus.59892 acts as an antioxidant protecting against hydrogen peroxide and hydroxyl radicals. Strong, broad functional edge across taxa.
  • orange pigmented has material basis in carotenoid accumulation

    The orange-pigmented phenotype is materially based on carotenoid accumulation.

    • DOI:10.7759/cureus.59892 orange carotenoid; golden yellow-orange pigment. High-level edge suitable for TraitMech root graph across diverse taxa.

Provenance

Source
METPO (2025-11-25)
Definition source
DOI:10.1080/1040841X.2025.2526423

Parent traits (1)

Synonyms (1)

  • Pigment_orange RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1003026 [-1.743, -2.814, -1.192, -0.288, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · CURATED_WITH_LITERATURE · codex

    Added DOI-backed definition and causal graph for Crt enzymes, carotenoid biosynthesis, orange carotenoids, staphyloxanthin, and visible orange color.

  3. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×2).

  4. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:catalyzes×1, biolink:causes×1).

  5. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007400×1).

  6. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0016117×1).

  7. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:71690×1).

  8. · ENRICH_CAUSAL_GRAPH · claude

    Added 7 evidence-backed generic edges (9 new nodes) from the deep-research report.

  9. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002326×1).

  10. · GROUND_CAUSAL_NODES · claude

    Grounded 3 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:15948×1, CHEBI:17579×1, CHEBI:27547×1).