cell length large

Edge evidence

• fast elongation rate contributes to cell length large RO:0002326

  Fast elongation between divisions yields longer cells.

  • DOI:10.1126/science.aaa1313 cell size scales with growth rate Supports fast growth as a producer of larger cell sizes.
• division-timing delay contributes to cell length large RO:0002326

  Delaying division allows continued elongation past the typical size.

  • DOI:10.1038/nrmicro2671 directs cell division Supports division timing as a control point for cell length.
• cell length large is a cell length rdfs:subClassOf

  Large cell length is a quantitative bin of the cell-length phenotype.

  • DOI:10.1016/j.cub.2014.07.022 cell size is tightly controlled Supports large length as a value within the regulated cell-length distribution.
• SOS response induces SulA-mediated division inhibition

  DNA damage/stress activates the SOS program, inducing division inhibitors that halt septation and promote elongation.

  • DOI:10.1101/2025.05.13.653778 SOS regulon upregulates sulA; SulA prevents Z-ring formation and halts division.
• SulA inhibits assembly of FtsZ Z-ring

  SulA blocks FtsZ polymerization/assembly, delaying cytokinesis and allowing continued elongation.

  • DOI:10.1101/2025.05.13.653778 Canonical edge for many bacteria: SulA inhibits FtsZ assembly by sequestering monomers, directly blocking polymerization.
• FtsZ delays onset of constriction

  FtsZ copy number is rate-limiting for division; reduced FtsZ delays septation and can increase cell length before division.

  • DOI:10.1038/s41467-024-54242-w FtsZ numbers are rate-limiting for cell division; ~20% downregulation may delay division.