temperature optimum mid3

Edge evidence

• upper-mesophilic environment engages upper-mesophile adaptation

  Upper-mesophilic environments engage upper-mesophile adaptation.

  • DOI:10.1146/annurev-micro-091313-103612 more unsaturated fatty acids Supports homoviscous adaptation at upper-mesophilic temperatures.
• upper-mesophile adaptation produces temperature optimum mid3 METPO:2000202

  Upper-mesophile adaptation yields a 30–34 °C optimum.

  • DOI:10.1146/annurev-micro-091313-103612 more unsaturated fatty acids Supports the 30–34 °C optimum as the upper-mesophile outcome.
• temperature optimum mid3 is a temperature optimum rdfs:subClassOf

  Temperature optimum mid3 is a quantitative bin of the temperature-optimum phenotype.

  • DOI:10.1016/s0300-9629(97)00003-0 adapted to environments of high temperature Supports the 30–34 °C optimum as a value within the temperature-optimum distribution.
• decreased temperature rigidifies membrane bilayer

  Cooler conditions rigidify and thicken the membrane bilayer, triggering fluidity-restoring responses.

  • DOI:10.1128/spectrum.03925-23 Core homeoviscous trigger: "upon temperature decrease the membrane rigidifies and thickens."
• homeoviscous adaptation restores liquid-crystalline membrane state

  Homeoviscous adaptation restores the fluid, liquid-crystalline membrane state across mesophilic temperatures.

  • DOI:10.1007/s42770-023-01057-4 General process-level support: "These changes are often referred to as homeoviscous adaptation."
• monounsaturated fatty acid incorporation increases membrane fluidity RO:0002213

  Incorporation of cis-monounsaturated fatty acids increases membrane fluidity at lower temperatures.

  • DOI:10.1007/s42770-023-01057-4 "The most common adaptation is the incorporation of monounsaturated fatty acids (MUFA), preferably cis-unsaturated ones."
• molecular chaperone network maintains proteostasis

  The chaperone network prevents and resolves aggregates, maintaining proteostasis during temperature shifts.

  • DOI:10.1007/s12275-023-00031-x General proteostasis module: "DnaK-DnaJ, GroEL-GroES, HtpG, ClpB" prevent/resolve aggregates.