thermophilic

Edge evidence

• high temperature selects for thermophilic METPO:2007401

  High-temperature environments select for thermophilic growth capacity.

  • DOI:10.1016/s0300-9629(97)00003-0 adapted to environments of high temperature Review supports thermophile adaptation to high-temperature environments.
• high temperature increases membrane proton permeability RO:0002213

  Elevated temperature increases proton permeability of the cytoplasmic membrane.

  • DOI:10.1016/s0300-9629(97)00003-0 proton permeability ... increase with the temperature Supports membrane proton permeability as a high-temperature growth constraint.
• membrane lipid composition limits membrane proton permeability RO:0002212

  Lipid composition changes can reduce high-temperature membrane leakiness.

  • DOI:10.1016/s0300-9629(97)00003-0 changing the lipid composition Supports lipid composition as an adaptation to membrane permeability.
• thermostable proteins enables thermophilic RO:0002327

  Thermostable proteins retain function during elevated-temperature growth.

  • DOI:10.1128/MMBR.65.1.1-43.2001 resistant to irreversible inactivation at high temperatures Supports thermostability as a high-temperature enzyme feature.
• energy-transducing enzymes enables thermophilic RO:0002327

  Adapted energy-transducing enzymes support growth at elevated temperature.

  • DOI:10.1016/s0300-9629(97)00003-0 energy transducing enzymes Review cites higher turnover rates and coupling-ion changes in high-temperature adaptation.
• reverse gyrase introduces positive DNA supercoiling

  Reverse gyrase introduces positive supercoils into thermophile DNA.

  • DOI:10.1264/jsme2.me23087 Takemata 2024: "reverse gyrase introduces positive supercoils" (broadly accepted in thermophile genomics).
• positive DNA supercoiling limits DNA melting RO:0002212

  Positive DNA supercoiling limits thermal DNA melting, protecting genome integrity.

  • DOI:10.1264/jsme2.me23087 Takemata 2024: "maintain the genome integrity of thermophiles by limiting DNA melting"; mechanism generalized across thermophiles.
• reverse gyrase mediates genome integrity maintenance

  Reverse gyrase mediates DNA repair and genome-integrity maintenance in thermophiles.

  • DOI:10.1264/jsme2.me23087 Takemata 2024: "maintain the genome integrity of thermophiles by ... mediating DNA repair".
• group II chaperonin (thermosome) refolds denatured proteins

  The group II chaperonin (thermosome) refolds denatured proteins in an ATP-dependent manner.

  • DOI:10.1128/mbio.03593-22 Baes 2023: "thermosome, which refolds proteins in an ATP-dependent manner".
• tetraether lipid cyclopentane ring number increases membrane rigidity RO:0002213

  Increased cyclopentane ring number in tetraether lipids increases membrane condensation and rigidity.

  • DOI:10.3389/frbis.2023.1338019 Chong 2024: "cyclopentane ring cyclization ... increase membrane condensation, packing tightness, rigidity".