temperature preference

Edge evidence

• environmental temperature regulates microbial growth rate RO:0002211

  Microbial growth rate varies with growth temperature.

  • DOI:10.1038/sj.jim.2900572 growth rate vs temperature Study analyzes temperature dependence of microbial growth rates across psychrotrophs, mesophiles, and thermophiles.
• low temperature decreases membrane fluidity RO:0002212

  Cold temperature reduces membrane fluidity and transport efficiency.

  • DOI:10.1038/sj.embor.7400662 decreased membrane fluidity Review identifies membrane fluidity loss as a core cold challenge.
• high temperature challenges protein stability METPO:2007406

  Elevated temperature challenges protein folding and functional stability.

  • DOI:10.1128/MMBR.65.1.1-43.2001 resistant to irreversible inactivation at high temperatures Review supports thermostable enzymes as a high-temperature adaptation.
• high temperature increases membrane fluidity RO:0002213

  High temperature increases membrane permeability and fluidity, creating a limit on growth.

  • DOI:10.1016/s0300-9629(97)00003-0 proton permeability ... increase with the temperature Review links increased membrane permeability to upper temperature growth limits.
• membrane fluidity regulates temperature preference RO:0002211

  Temperature preference reflects the range in which membrane function remains compatible with growth.

  • DOI:10.1146/annurev-micro-091313-103612 optimizes the performance of cellular physiological processes Review supports membrane fluidity adaptation as a temperature-sensing and response mechanism.
• protein stability regulates temperature preference RO:0002211

  Growth at preferred temperatures requires proteins to remain active and stable.

  • DOI:10.1128/MMBR.65.1.1-43.2001 molecular mechanisms involved in protein thermostabilization Supports protein stability as a determinant of high-temperature growth.
• fatty acid desaturase increases unsaturated membrane fatty acids RO:0002213

  Desaturase expression increases double bonds in membrane fatty acids (homeoviscous adaptation).

  • DOI:10.1007/s42770-023-01057-4 Activation of des (desaturase) transcription increases double bonds in membrane fatty acids; generic UFA-biosynthesis module.
• unsaturated membrane fatty acids increases membrane fluidity RO:0002213

  Increased unsaturated membrane fatty acids restore/raise membrane fluidity.

  • DOI:10.1007/s42770-023-01057-4 Increasing double bonds in membrane fatty acids restores membrane fluidity; core homeoviscous-adaptation edge broadly curatable across microbes.
• high temperature melts RNA thermometer

  Elevated temperature melts RNA thermometer hairpins, relieving translational repression.

  • DOI:10.1007/s12275-023-00031-x RNA thermometers (ROSE/FourU) control translation by occluding Shine-Dalgarno/start codons and melt with temperature; bacterial heat-sensing mechanism.
• RNA thermometer permits translation of heat-shock gene translation

  RNA thermometer melting permits translation of heat-shock genes.

  • DOI:10.1007/s12275-023-00031-x Post-transcriptional RNA thermometers in 5-UTRs mediate rapid temperature-dependent control of translation; strong generic edge.
• low temperature induces cold-shock RNA chaperone activity

  Cold shock induces CspA-mediated RNA chaperone activity that maintains translatable RNA.

  • DOI:10.1007/s12275-023-00031-x Cold shock induces cold-shock proteins (CspA) that help maintain single-stranded RNA for translation at low temperature.
• temperature downshift induces fatty acid desaturase

  Cold downshift induces fatty-acid desaturase activity to maintain membrane fluidity.

  • DOI:10.1038/sj.jim.2900572 Connecting edge wiring the enrichment node into the graph.