catalase activity

Edge evidence

• catalase enables catalase activity RO:0002327

  Catalase carries out the catalase molecular function.

  • DOI:10.1007/s00018-003-3206-5 Chelikani et al. characterize catalases as the enzymes performing this dismutation.
• catalase activity consumes hydrogen peroxide biolink:consumes

  The catalase reaction consumes hydrogen peroxide.

  • DOI:10.1038/nrmicro3032 Imlay supports catalase as a primary hydrogen-peroxide scavenging defense.
• catalase activity produces molecular oxygen METPO:2000202

  The catalase reaction produces molecular oxygen.

  • DOI:10.1007/s00018-003-3206-5 Catalase dismutation yields O2 (2 H2O2 to O2 + 2 H2O).
• catalase activity produces water METPO:2000202

  The catalase reaction produces water.

  • DOI:10.1007/s00018-003-3206-5 Catalase dismutation yields water.
• catalase enables catalase activity RO:0002327

  Production of catalase confers the catalase-activity phenotype.

  • DOI:10.1007/s00018-003-3206-5 Supports catalase possession as the basis of the catalase-activity phenotype.
• catalase activity decomposes hydrogen peroxide

  Catalase activity rapidly decomposes hydrogen peroxide into water and molecular oxygen.

  • DOI:10.3390/biom14060697 Catalase rapidly decomposes hydrogen peroxide into water and molecular oxygen (canonical enzymology).
• hydrogen peroxide activates OxyR RO:0002213

  Hydrogen peroxide activates the OxyR peroxide-sensing regulator.

  • DOI:10.1038/nrmicro3032 An intracellular H2O2 concentration of ~200 nM is sufficient to drive OxyR into a disulfide-bonded (active) form.
• hydrogen peroxide favors scavenging by catalase activity

  High hydrogen peroxide concentrations favor scavenging by catalases, which turn over much faster than alkyl hydroperoxide reductase.

  • DOI:10.1038/nrmicro3032 Organisms rely on catalases when H2O2 levels are high; catalases turn over much more quickly than Ahp. Likely general across aerobes/facultative anaerobes.
• OxyR regulates peroxide defense systems RO:0002211

  OxyR regulates peroxide defense systems; most bacteria sense H2O2 via OxyR or PerR.

  • DOI:10.3389/fimmu.2021.667343 Most bacteria sense H2O2 via OxyR or PerR transcription factors that control peroxide defense systems.
• PerR regulates peroxide defense systems RO:0002211

  PerR regulates peroxide defense systems; most bacteria sense H2O2 via OxyR or PerR.

  • DOI:10.3389/fimmu.2021.667343 Most bacteria sense H2O2 via OxyR or PerR transcription factors that control peroxide defense systems.
• heme biosynthesis required for catalase

  Heme biosynthesis is required for catalase activation; impaired heme synthesis delays peroxide degradation.

  • DOI:10.1111/mmi.12967 Ferrochelatase (hemH) function is required for timely induction of catalase (KatG) activity; loss delays H2O2 degradation and growth.