chemolithotrophic

METPO:1000639 · CLASS · REVIEWED

A trophic type characterized by the use of inorganic chemical compounds as electron donors and carbon dioxide as the primary carbon source for energy generation and biosynthesis.

Chemolithotrophic inorganic chemical oxidation

DOI-backed graph for inorganic chemical electron donors, representative ammonia and sulfur oxidation, and respiratory energy conservation.

Chemolithotrophic inorganic chemical oxidation Interactive directed graph showing evidence-backed causal relationships for chemolithotrophic.

Edge evidence

  • chemolithotrophic uses electron donor inorganic chemical electron donor METPO:2000009

    Chemolithotrophy uses inorganic chemicals as electron donors.

    • DOI:10.1016/B978-0-12-378630-2.00219-X oxidize inorganic atoms or molecules Supports inorganic chemical oxidation as chemolithotrophy.
  • ammonia monooxygenase oxidizes ammonia METPO:2000016

    Ammonia monooxygenase initiates ammonia oxidation.

    • DOI:10.1146/annurev.micro.55.1.485 ammonia-oxidizing bacteria Supports ammonia oxidation as a chemolithoautotrophic process.
  • ammonia oxidized to hydroxylamine METPO:2007405

    Ammonia oxidation proceeds through hydroxylamine.

    • DOI:10.1007/s00775-020-01820-0 convert ammonia to hydroxylamine Supports AMO-catalyzed ammonia-to-hydroxylamine conversion.
  • hydroxylamine oxidized to nitrite METPO:2007405

    Hydroxylamine oxidation yields nitrite in ammonia oxidizers.

    • DOI:10.3389/fmicb.2012.00210 oxidation of hydroxylamine to nitrite Supports hydroxylamine oxidation as the next nitrification step.
  • Sox enzyme system oxidizes thiosulfate METPO:2000016

    Sox proteins mediate oxidation of reduced sulfur compounds such as thiosulfate.

    • DOI:10.1111/j.1574-6976.2009.00187.x oxidation of thiosulfate Supports the Sox multienzyme system in lithotrophic sulfur oxidation.
  • inorganic chemical electron donor feeds electrons into respiratory chain METPO:2007402

    Oxidation of inorganic donors feeds electrons into respiratory chains.

    • DOI:10.1016/j.bbabio.2008.09.008 membrane-bound electron transport chain Supports respiratory chains as energy-conserving redox systems.
  • respiratory chain produces ATP METPO:2000202

    Respiratory energy conservation produces ATP.

    • DOI:10.1016/j.bbabio.2008.09.008 drives ATP synthesis Supports ATP synthesis from the respiratory ion gradient.
  • Calvin-Benson-Bassham cycle mediates fixation of carbon dioxide

    Chemolithoautotrophs fix CO2 via the Calvin-Benson-Bassham cycle.

    • DOI:10.3390/microorganisms12030590 fixes atmospheric CO2 via the Calvin-Benson-Bassham (CBB) cycle
  • acidification decreases nitrification rate RO:0002212

    Environmental acidification reduces nitrification rates.

    • DOI:10.1038/s41467-023-37104-9 a 5.8-18.1% drop and ~11.1-34.1% decline when pCO2 was doubled
  • acidification stimulates generation of nitrous oxide

    Acidification stimulates N2O byproduct generation during nitrification.

    • DOI:10.1038/s41467-023-37104-9 Acidification also stimulate[s] generation of byproduct nitrous oxide (N2O)

Provenance

Source
METPO (2025-11-25)
Author
Anthea Guo
Definition source
DOI:10.1016/B978-0-12-378630-2.00219-X

Parent traits (1)

Synonyms (1)

  • chemolithotroph RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1000639 [-0.145, -1.567, -3.045, -0.245, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · ADDED_CAUSAL_GRAPH · codex

    Added DOI-backed causal graph for inorganic chemical electron donors, ammonia oxidation, sulfur oxidation, respiratory energy conservation, and ATP synthesis.

  3. · ADDED_ORGANISM_EXAMPLE · claude

    Added Nitrosomonas europaea organism example with PMID-backed evidence.

  4. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 4 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000016×2, METPO:2000009×1, METPO:2000202×1).

  5. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 3 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007405×2, METPO:2007402×1).

  6. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0022904×1).

  7. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (UniProtKB:A0A059V4Z9×1).

  8. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:33542×1).

  9. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:15429×1).

  10. · FIX_NODE_GROUNDING_CURIE · claude

    Overwrote 1 causal-node grounding(s) to corrected CURIEs (phase-2 id-label fix; verified vs OAK).

  11. · ENRICH_CAUSAL_GRAPH · claude

    Added 3 evidence-backed generic edges (5 new nodes) from the deep-research report.

  12. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002212×1).

  13. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:17045×1).