chemolithotrophic
METPO:1000639 · CLASS · REVIEWED
A trophic type characterized by the use of inorganic chemical compounds as electron donors and carbon dioxide as the primary carbon source for energy generation and biosynthesis.
Chemolithotrophic inorganic chemical oxidation
Edge evidence
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chemolithotrophic
uses electron donor
inorganic chemical electron donor
METPO:2000009Chemolithotrophy uses inorganic chemicals as electron donors.
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DOI:10.1016/B978-0-12-378630-2.00219-Xoxidize inorganic atoms or molecules
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ammonia monooxygenase
oxidizes
ammonia
METPO:2000016Ammonia monooxygenase initiates ammonia oxidation.
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DOI:10.1146/annurev.micro.55.1.485ammonia-oxidizing bacteria
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ammonia
oxidized to
hydroxylamine
METPO:2007405Ammonia oxidation proceeds through hydroxylamine.
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DOI:10.1007/s00775-020-01820-0convert ammonia to hydroxylamine
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hydroxylamine
oxidized to
nitrite
METPO:2007405Hydroxylamine oxidation yields nitrite in ammonia oxidizers.
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DOI:10.3389/fmicb.2012.00210oxidation of hydroxylamine to nitrite
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Sox enzyme system
oxidizes
thiosulfate
METPO:2000016Sox proteins mediate oxidation of reduced sulfur compounds such as thiosulfate.
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DOI:10.1111/j.1574-6976.2009.00187.xoxidation of thiosulfate
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inorganic chemical electron donor
feeds electrons into
respiratory chain
METPO:2007402Oxidation of inorganic donors feeds electrons into respiratory chains.
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DOI:10.1016/j.bbabio.2008.09.008membrane-bound electron transport chain
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respiratory chain
produces
ATP
METPO:2000202Respiratory energy conservation produces ATP.
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DOI:10.1016/j.bbabio.2008.09.008drives ATP synthesis
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Calvin-Benson-Bassham cycle
mediates fixation of
carbon dioxide
Chemolithoautotrophs fix CO2 via the Calvin-Benson-Bassham cycle.
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DOI:10.3390/microorganisms12030590
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acidification
decreases
nitrification rate
RO:0002212Environmental acidification reduces nitrification rates.
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DOI:10.1038/s41467-023-37104-9
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acidification
stimulates generation of
nitrous oxide
Acidification stimulates N2O byproduct generation during nitrification.
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DOI:10.1038/s41467-023-37104-9
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Provenance
- Source
- METPO (2025-11-25)
- Author
- Anthea Guo
- Definition source
- DOI:10.1016/B978-0-12-378630-2.00219-X
Parent traits (1)
Synonyms (1)
- chemolithotroph
kg-microbe context
Matched 1 kg-microbe node via direct_metpo.
METPO:1000639[-0.145, -1.567, -3.045, -0.245, …]
Nearest neighbors in embedding space
- physiology trophic type 0.677
- physiology hydrogenotrophic 0.657
- physiology carboxydotrophic 0.653
- physiology photolithoautotrophic 0.646
- physiology photoorganoheterotrophic 0.635
- physiology lithoautotrophic 0.625
- physiology chemoautotrophic 0.618
- physiology mixotrophic 0.617
Curation history
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SEEDED_FROM_METPO · seed_from_metpo
imported from data/raw/metpo.owl (CLASS)
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ADDED_CAUSAL_GRAPH · codex
Added DOI-backed causal graph for inorganic chemical electron donors, ammonia oxidation, sulfur oxidation, respiratory energy conservation, and ATP synthesis.
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ADDED_ORGANISM_EXAMPLE · claude
Added Nitrosomonas europaea organism example with PMID-backed evidence.
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GROUND_CAUSAL_PREDICATES · claude
Grounded 4 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000016×2, METPO:2000009×1, METPO:2000202×1).
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GROUND_CAUSAL_PREDICATES · claude
Grounded 3 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007405×2, METPO:2007402×1).
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GROUND_CAUSAL_NODES · claude
Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0022904×1).
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GROUND_CAUSAL_NODES · claude
Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (UniProtKB:A0A059V4Z9×1).
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GROUND_CAUSAL_NODES · claude
Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:33542×1).
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GROUND_CAUSAL_NODES · claude
Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:15429×1).
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FIX_NODE_GROUNDING_CURIE · claude
Overwrote 1 causal-node grounding(s) to corrected CURIEs (phase-2 id-label fix; verified vs OAK).
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ENRICH_CAUSAL_GRAPH · claude
Added 3 evidence-backed generic edges (5 new nodes) from the deep-research report.
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GROUND_CAUSAL_PREDICATES · claude
Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002212×1).
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GROUND_CAUSAL_NODES · claude
Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:17045×1).