Substrate-level phosphorylation

Edge evidence

• Substrate-level phosphorylation occurs in fermentative condition biolink:occurs_in

  SLP is a major ATP source in fermentative energy metabolism.

  • DOI:10.1111/1751-7915.13746 main sources of energy under fermentative conditions Supports fermentative context for SLP.
• high-energy phosphorylated intermediate donates phosphoryl group to ADP

  SLP transfers phosphoryl groups from metabolic intermediates to ADP.

  • DOI:10.1111/1751-7915.13746 transferring a phosphate group to ADP Supports direct phosphoryl transfer to ADP.
• kinase reaction produces ATP METPO:2000202

  Kinase reactions convert phosphorylated intermediates and ADP to ATP.

  • DOI:10.1111/1751-7915.13746 kinase-catalysed reactions can be applied for SLP Supports kinase-mediated ATP formation.
• acetyl phosphate substrate for acetate kinase

  Acetyl phosphate is converted by acetate kinase during acetate dissimilation.

  • DOI:10.1128/MMBR.69.1.12-50.2005 Acetyl phosphate ... high-energy intermediate Supports acetyl phosphate as the high-energy acetate-switch intermediate.
• acetate kinase produces acetate METPO:2000202

  Acetate kinase forms acetate from acetyl phosphate.

  • DOI:10.1128/MMBR.69.1.12-50.2005 phosphotransacetylase [PTA], acetate kinase [ACK] Supports acetate kinase as a central acetate-switch component.
• acetate kinase produces ATP METPO:2000202

  Acetate kinase contributes ATP formation through substrate-level phosphorylation.

  • DOI:10.1111/1751-7915.13746 acetyl-phosphate to acetate Review lists acetyl-phosphate to acetate among SLP energy-conserving reactions.
• anaerobiosis / low oxygen enables fermentation RO:0002327

  Absence of oxygen enables fermentative metabolism.

  • DOI:10.1093/femsre/fuae016 Fermentation is a type of metabolism carried out by organisms in environments without oxygen.
• fermentation produces ATP via Substrate-level phosphorylation

  In fermentation, ATP is produced by substrate-level phosphorylation.

  • DOI:10.1093/femsre/fuae016 ATP is produced by substrate-level phosphorylation; strong definitional edge.
• AckA-Pta pathway allows ATP production via Substrate-level phosphorylation

  The AckA-Pta reaction set allows ATP production via substrate-level phosphorylation.

  • DOI:10.1042/ETLS20220092 AckA-Pta, a set of reactions that allows ATP production via substrate-level phosphorylation.
• carbamate kinase (arginine deiminase pathway) generates ATP via Substrate-level phosphorylation

  Carbamate kinase in the arginine deiminase pathway is an additional SLP route for ATP production.

  • DOI:10.1039/d4cb00099d The carbamate kinase reaction has been reported to be effective for ATP production in several acetogens.