spore germination

Edge evidence

• germinant causes spore germination biolink:causes

  Germinant binding triggers the germination process.

  • DOI:10.1016/j.mib.2003.10.001 Setlow reviews germinant-triggered spore germination.
• spore germination enables spore germination RO:0002327

  The germination process realizes the spore-germination trait.

  • DOI:10.1038/nrmicro2504 Lennon & Jones frame germination as resuscitation from dormancy.
• spore germination causes CaDPA release from spore core biolink:causes

  The germination process drives SpoVA-mediated release of calcium dipicolinate from the spore core.

  • DOI:10.1126/science.adg9829 Ion release during germination drives expulsion of dipicolinic acid (CaDPA) through the SpoVA transport complex.
• CaDPA release from spore core activates cortex peptidoglycan hydrolysis RO:0002213

  Released CaDPA acts as a signal activating germination-specific cortex-lytic enzymes to begin cortex degradation.

  • DOI:10.1128/mbio.02220-23 Ca-DPA release acts as a signal for a germination-specific cortex-lytic enzyme to begin cortex degradation.
• cortex peptidoglycan hydrolysis causes core rehydration and outgrowth biolink:causes

  Once the cortex is hydrolyzed, the core can fully expand and rehydrate, enabling outgrowth.

  • DOI:10.1128/mbio.02220-23 Once the cortex is hydrolyzed, the core can fully expand and rehydrate, allowing full metabolic capabilities and initiation of outgrowth; broadly supported across endospore formers.
• core rehydration and outgrowth enables spore germination RO:0002327

  Core rehydration and outgrowth complete realization of the spore-germination trait.

  • DOI:10.1128/mbio.02220-23 Core rehydration following cortex hydrolysis allows full metabolic capabilities and initiation of outgrowth, completing germination.