chemoautolithotrophic

METPO:1000634 · CLASS · REVIEWED

A trophic type in which an organism uses chemical oxidation of inorganic compounds as the energy source and carbon dioxide as the primary carbon source for biosynthesis.

Chemoautolithotrophic inorganic energy and CO2 fixation

DOI-backed graph linking inorganic chemical donors, respiratory energy conservation, CO2 fixation, and biomass production.

Chemoautolithotrophic inorganic energy and CO2 fixation Interactive directed graph showing evidence-backed causal relationships for chemoautolithotrophic.

Edge evidence

  • chemoautolithotrophic uses electron donor inorganic electron donor METPO:2000009

    Chemoautolithotrophy uses inorganic chemical electron donors for energy.

    • DOI:10.1016/B978-0-12-378630-2.00219-X oxidize inorganic atoms or molecules Supports lithotrophic oxidation of inorganic substrates.
  • ammonia example of inorganic electron donor rdfs:subClassOf

    Ammonia is an inorganic donor in chemolithoautotrophic nitrification.

    • DOI:10.1146/annurev.micro.55.1.485 Chemolitho-autotrophic ammonia-oxidizing bacteria Supports ammonia oxidation as a chemolithoautotrophic example.
  • ferrous iron example of inorganic electron donor rdfs:subClassOf

    Fe(II) is a representative inorganic electron donor.

    • DOI:10.1038/s41598-021-81412-3 Fe(II) as the energy source Supports Fe(II) oxidation as an inorganic energy source.
  • inorganic electron donor feeds electrons into respiratory chain METPO:2007402

    Inorganic donor oxidation feeds respiratory energy conservation.

    • DOI:10.1016/j.bbabio.2008.09.008 membrane-bound electron transport chain Supports respiratory electron transfer as energy-conserving pathway.
  • respiratory chain produces ATP METPO:2000202

    Respiratory energy conservation produces ATP.

    • DOI:10.1016/j.bbabio.2008.09.008 drives ATP synthesis Supports ATP production from electron transport.
  • chemoautolithotrophic uses carbon source carbon dioxide METPO:2000006

    Chemoautolithotrophs use CO2 as the primary carbon source.

    • DOI:10.1128/AEM.02473-10 autotrophic CO2 fixation Supports inorganic carbon fixation by autotrophic pathways.
  • carbon dioxide fixed by CO2-fixation pathway METPO:2007404

    CO2 is fixed into cellular carbon by autotrophic pathways.

    • DOI:10.1128/AEM.02473-10 autotrophic carbon dioxide assimilation pathway Supports conversion of CO2 by microbial autotrophic pathways.
  • CO2-fixation pathway produces biomass METPO:2000202

    Fixed carbon supports biomass production.

    • DOI:10.1038/nrmicro.2016.130 microbial autotrophic production Supports biomass production from autotrophic CO2 fixation.
  • chemoautolithotrophic requires CO2-fixation pathway

    Chemoautolithotrophy requires CO2 fixation to convert inorganic carbon into organic carbon.

    • DOI:10.1186/s40168-023-01712-w Chemolithoautotrophs convert CO2 to organic carbon (Deng et al. 2023).
  • chemoautolithotrophic requires oxidation of reduced inorganic compounds

    Chemoautolithotrophy requires oxidation of reduced inorganic compounds for energy.

    • DOI:10.1186/s40168-023-01712-w Using the energy produced by oxidizing reduced inorganic compounds (Deng et al. 2023).
  • oxidation of reduced inorganic compounds feeds electrons into respiratory chain METPO:2007402

    Oxidation of reduced inorganic compounds donates electrons to the respiratory chain.

    • DOI:10.1186/s40168-023-01712-w Energy produced by oxidizing reduced inorganic compounds is conserved via electron transport (Deng et al. 2023).
  • chemoautolithotrophic distinct from chemo-organoheterotrophy

    Chemolithoautotrophy (inorganic energy, CO2 carbon) is metabolically distinct from chemo-organoheterotrophy (organic energy and carbon).

    • DOI:10.3390/molecules29102293 Chemolithoautotrophy oxidizes inorganic compounds versus chemo-organoheterotrophs using glucose (Fukala & Kucera 2024).

Provenance

Source
METPO (2025-11-25)
Author
Luke Wang
Definition source
DOI:10.1016/B978-0-12-378630-2.00219-X

Parent traits (1)

Synonyms (1)

  • chemoautolithotroph RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1000634 [-0.916, -0.754, -3.630, +1.094, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · CURATED_CAUSAL_GRAPH · Codex

    Added DOI-backed chemoautolithotrophy graph for inorganic electron donors, respiratory ATP generation, CO2 fixation, and biomass.

  3. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 4 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×2, METPO:2000009×1, METPO:2000006×1).

  4. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (rdfs:subClassOf×2).

  5. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007402×1, METPO:2007404×1).

  6. · GROUND_CAUSAL_NODES · claude

    Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:29033×1, GO:0022904×1).

  7. · GROUND_CAUSAL_NODES · claude

    Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (METPO:1007502×1, METPO:1007501×1).

  8. · RETYPE_CAUSAL_NODES · claude

    Re-typed 1 causal-node node_type field(s) to align with CausalNodeTypeEnum semantics: biomass: BIOLOGICAL_PROCESS → CHEMICAL ×1.

  9. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (GO:0015977×1).

  10. · ENRICH_CAUSAL_GRAPH · claude

    Added 4 evidence-backed generic edges (2 new nodes) from the deep-research report.

  11. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007402×1).