oxidative stress response

Edge evidence

• hydrogen peroxide causes response to oxidative stress biolink:causes

  Reactive oxygen species trigger the oxidative-stress response.

  • DOI:10.1038/nrmicro3032 Imlay reviews ROS damage and induced defenses.
• response to oxidative stress enables oxidative stress response RO:0002327

  The induced defense realizes the oxidative-stress-response trait.

  • DOI:10.1007/s00018-003-3206-5 Chelikani et al. support catalases as core oxidative-stress enzymes.
• OxyR transcriptional regulator positively regulates response to oxidative stress

  OxyR activates transcription of genes that defend the cell against oxidative stress.

  • DOI:10.1099/mic.0.001481 OxyR is widely conserved in bacteria and activates transcription of a set of genes that influence cellular defence against oxidative stress.
• RpoS (sigma-S) general stress sigma factor positively regulates response to oxidative stress

  The general stress sigma factor RpoS controls oxidative-stress defense outputs; its loss increases sensitivity to oxidative stress.

  • DOI:10.1128/mmbr.00151-22 Cells devoid of RpoS are sensitive to oxidative stress; the RpoS regulon includes oxidative-stress genes (dps, catalases, sodA, osmC).
• thioredoxin system contributes to response to oxidative stress RO:0002326

  Thioredoxin thiol-repair systems support survival under oxidative/oxidant stress, including in anaerobes and spores.

  • DOI:10.1371/journal.ppat.1012001 Multiple thioredoxin systems are involved in the response to oxidative stresses, broadening thiol-repair scope beyond classic aerobes.