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stress response

traitmech:000078 · CLASS · REVIEWED

A physiological program by which a cell senses and mounts a protective response to environmental or cellular stress, such as the RpoS-mediated general stress response of enteric bacteria.

Stress-induced protective response

Evidence-backed causal sketch linking environmental stress to an induced, protective general stress response.

Stress-induced protective response Interactive directed graph showing evidence-backed causal relationships for stress response.

Edge evidence

  • environmental stress causes response to stress biolink:causes

    A stressor triggers the stress-response program.

    • DOI:10.1146/annurev-micro-090110-102946 Battesti et al. review stress/stationary-phase induction of RpoS.
  • response to stress enables stress response RO:0002327

    The induced program realizes the stress-response trait.

    • DOI:10.1038/nrmicro3032 Imlay reviews inducible molecular stress defenses.
  • RelA/SpoT homologue enzymes synthesizes/hydrolyzes (p)ppGpp

    RSH enzymes synthesize and hydrolyze the (p)ppGpp alarmone.

    • DOI:10.1099/mic.0.001483 (p)ppGpp is synthesized and hydrolysed by RelA-SpoT homologue (RSH) enzymes; broadly conserved in bacteria.
  • nutrient limitation triggers (p)ppGpp

    Nutrient-limiting conditions trigger a surge of (p)ppGpp.

    • DOI:10.1099/mic.0.001483 Stringent response mediated by (p)ppGpp, whose intracellular surge is triggered by nutrient-limiting conditions.
  • (p)ppGpp inhibits ribosome biosynthesis RO:0002212

    (p)ppGpp inhibits ribosome biosynthesis, slowing growth.

    • DOI:10.1099/mic.0.001483 (p)ppGpp inhibits ribosome biosynthesis, inducing a slow-growth phenotype.
  • (p)ppGpp enhances stress tolerance

    Moderate (p)ppGpp induction enhances stress tolerance.

    • DOI:10.1016/j.isci.2024.108818 Moderate induction of (p)ppGpp reduces growth rate while enhancing stress tolerance.
  • (p)ppGpp positively regulates RpoS (sigma S)

    (p)ppGpp positively regulates RpoS abundance/activity.

    • DOI:10.1016/j.isci.2024.108818 (p)ppGpp positively regulates RpoS by transcriptional activation and by inhibiting RpoS proteolysis.
  • RpoS (sigma S) induces general stress resistance

    RpoS-dependent gene expression induces general stress resistance.

    • DOI:10.1146/annurev-micro-090110-102946 RpoS-dependent gene expression leads to general stress resistance of cells.
  • Hfq enables RpoS (sigma S) RO:0002327

    Hfq enables sRNA-dependent translation of RpoS.

    • DOI:10.1128/mmbr.00151-22 Hfq is needed for sRNA-dependent RpoS translation.
  • general stress resistance enables stress response RO:0002327

    General stress resistance realizes the stress-response trait.

    • DOI:10.1146/annurev-micro-090110-102946 RpoS-mediated general stress resistance is the protective program defining the trait.

Provenance

Source
METPO (2025-11-25)
Definition source
DOI:10.1146/annurev-micro-090110-102946

Parent traits (1)

Children (1)

Synonyms (1)

  • general stress response RELATED_SYNONYM · DOI:10.1146/annurev-micro-090110-102946

kg-microbe context

Matched 1 kg-microbe node via parent_proxy.

  • METPO:1000059 [-2.682, -2.070, -3.656, -0.652, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · PROPOSED_FROM_RESEARCH · claude

    Proposed candidate PHYSIOLOGY axis class (stress response) to parent specific stress-response sub-variants.

  2. · CURATED_CAUSAL_GRAPH · claude

    Added evidence-backed causal graph (stress-induced protective response) with GO node grounding and biolink/RO predicate groundings; promoted PROPOSED to REVIEWED.

  3. · ENRICH_CAUSAL_GRAPH · claude

    Added 8 evidence-backed generic edges (8 new nodes) from the deep-research report.

  4. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 3 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002327×2, RO:0002212×1).

  5. · GROUND_CAUSAL_NODES · claude

    Grounded 2 causal-node grounding field(s) via mappings/node_grounding.tsv (UniProtKB:A0A010TBV5×1, UniProtKB:A0A3B9B147×1).