DUFMech families

Families

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8,296 of 8,296 families. Page 4 of 166.

Pfam	Family	Seed status	Characterization	Evidence counts	Proteins	Structures	AlphaFold	Other Mechs	Curation status
PF04075	F420H(2)-dependent quinone reductase F420H2_quin_red	EX DUF	UNSCORED	Not scored	16,735	12	9,873	not covered by the cross-Mech scan	SEEDED
PF13186	Iron-sulfur cluster-binding domain SPASM	EX DUF	UNSCORED	Not scored	16,680	10	11,292	not covered by the cross-Mech scan	SEEDED
PF02645	Uncharacterised protein, DegV family COG1307 DegV	EX DUF	UNSCORED	Not scored	16,441	30	10,587	not covered by the cross-Mech scan	SEEDED
PF09346	SMI1 / KNR4 family (SUKH-1) SMI1_KNR4	EX DUF	UNSCORED	Not scored	16,439	11	9,960	not covered by the cross-Mech scan	SEEDED
PF13349	Toastrack DUF4097 DUF4097	UNKNOWN CANDIDATE	UNSCORED	Not scored	16,423	0	10,032	ProteinTraitsMech: 6; ProteinTraitsMech trait record	SEEDED
PF03619	Organic solute transporter Ostalpha Solute_trans_a	EX DUF	UNSCORED	Not scored	16,376	10	14,134	not covered by the cross-Mech scan	SEEDED
PF02626	Carboxyltransferase domain, subdomain A and B CT_A_B	EX DUF	UNSCORED	Not scored	16,267	8	9,634	not covered by the cross-Mech scan	SEEDED
PF04577	Glycosyltransferase 61 Glyco_transf_61	EX DUF	UNSCORED	Not scored	16,150	7	13,149	not covered by the cross-Mech scan	SEEDED
PF09594	Glycosyltransferase family 87 GT87	EX DUF	UNSCORED	Not scored	16,098	3	9,401	not covered by the cross-Mech scan	SEEDED
PF02682	Carboxyltransferase domain, subdomain C and D CT_C_D	EX DUF	UNSCORED	Not scored	16,088	11	9,538	not covered by the cross-Mech scan	SEEDED
PF07331	Tripartite tricarboxylate transporter TctB family TctB	EX DUF	UNSCORED	Not scored	16,049	0	10,334	not covered by the cross-Mech scan	SEEDED
PF06974	WS/DGAT C-terminal domain WS_DGAT_C	EX DUF	UNSCORED	Not scored	16,019	2	11,175	not covered by the cross-Mech scan	SEEDED
PF05960	Bacterial protein of unknown function (DUF885) DUF885	UNKNOWN CANDIDATE	UNSCORED	Not scored	16,004	3	9,783	ProteinTraitsMech trait record	SEEDED
PF13959	ATP-dependent rRNA helicase SPB4-like, C-terminal extension CTE_SPB4	EX DUF	UNSCORED	Not scored	15,982	50	13,653	not covered by the cross-Mech scan	SEEDED
PF04143	Sulphur transport Sulf_transp	EX DUF	UNSCORED	Not scored	15,961	4	10,919	not covered by the cross-Mech scan	SEEDED
PF10035	Uncharacterized protein conserved in bacteria (DUF2179) DUF2179	KNOWN HISTORICAL DUF	UNSCORED	Not scored	15,886	1	10,419	ProteinTraitsMech: 8; ProteinTraitsMech trait record	SEEDED
PF05686	Glycosyl transferase family 90 Glyco_transf_90	EX DUF	UNSCORED	Not scored	15,884	11	13,251	not covered by the cross-Mech scan	SEEDED
PF31073	Domain of unknown function (DUF8803) DUF8803	UNKNOWN CANDIDATE	UNSCORED	Not scored	15,860	0	8,872	ProteinTraitsMech trait record	SEEDED
PF03713	Domain of unknown function (DUF305) DUF305	UNKNOWN CANDIDATE	UNSCORED	Not scored	15,758	11	9,380	ProteinTraitsMech: 1; ProteinTraitsMech trait record	SEEDED
PF01985	CRS1 / YhbY (CRM) domain CRS1_YhbY	EX DUF	UNSCORED	Not scored	15,752	6	11,674	not covered by the cross-Mech scan	SEEDED
PF01914	MarC family integral membrane protein MarC	EX DUF	UNSCORED	Not scored	15,684	0	10,306	not covered by the cross-Mech scan	SEEDED
PF01923	Cobalamin adenosyltransferase Cob_adeno_trans	EX DUF	UNSCORED	Not scored	15,667	52	10,554	not covered by the cross-Mech scan	SEEDED
PF06013	Proteins of 100 residues with WXG WXG100	EX DUF	UNSCORED	Not scored	15,659	24	9,559	not covered by the cross-Mech scan	SEEDED
PF14009	PADRE domain PADRE	EX DUF	UNSCORED	Not scored	15,658	0	12,753	not covered by the cross-Mech scan	SEEDED
PF05057	Putative serine esterase (DUF676) DUF676	UNKNOWN CANDIDATE	UNSCORED	Not scored	15,503	0	10,211	ProteinTraitsMech: 4; ProteinTraitsMech trait record	SEEDED
PF07394	Protein of unknown function (DUF1501) DUF1501	UNKNOWN CANDIDATE	UNSCORED	Not scored	15,357	0	11,045	ProteinTraitsMech trait record	SEEDED
PF04079	Segregation and condensation complex subunit ScpB SMC_ScpB	EX DUF	UNSCORED	Not scored	15,280	6	9,916	not covered by the cross-Mech scan	SEEDED
PF08338	Domain of unknown function (DUF1731) DUF1731	UNKNOWN CANDIDATE	UNSCORED	Not scored	15,266	2	9,814	ProteinTraitsMech: 5; ProteinTraitsMech trait record	SEEDED
PF01863	YgjP-like, metallopeptidase domain YgjP-like	EX DUF	UNSCORED	Not scored	15,247	2	9,610	not covered by the cross-Mech scan	SEEDED
PF12473	Kinesin protein DUF3694	KNOWN HISTORICAL DUF	UNSCORED	Not scored	15,238	0	3,731	ProteinTraitsMech: 3; ProteinTraitsMech trait record	SEEDED
PF02578	Multi-copper polyphenol oxidoreductase laccase Cu-oxidase_4	EX DUF	UNSCORED	Not scored	15,217	13	9,887	not covered by the cross-Mech scan	SEEDED
PF01957	NfeD-like C-terminal, partner-binding domain NfeD	EX DUF	UNSCORED	Not scored	15,192	5	9,701	not covered by the cross-Mech scan	SEEDED
PF03966	Trm112p-like protein Trm112p	EX DUF	UNSCORED	Not scored	15,167	41	10,889	not covered by the cross-Mech scan	SEEDED
PF03007	Wax ester synthase/diacylglycerol acyltransferase catalytic domain WS_DGAT_cat	EX DUF	UNSCORED	Not scored	15,050	2	10,311	not covered by the cross-Mech scan	SEEDED
PF05331	Protein of unknown function (DUF742) DUF742	UNKNOWN CANDIDATE	UNSCORED	Not scored	15,048	0	7,687	ProteinTraitsMech trait record	SEEDED
PF04525	LURP-one-related LOR	EX DUF	UNSCORED	Not scored	14,951	2	11,500	not covered by the cross-Mech scan	SEEDED
PF03458	Glycine transporter Gly_transporter	EX DUF	UNSCORED	Not scored	14,941	7	9,554	not covered by the cross-Mech scan	SEEDED
PF01796	ChsH2, C-terminal OB-fold domain OB_ChsH2_C	EX DUF	UNSCORED	Not scored	14,915	12	9,479	not covered by the cross-Mech scan	SEEDED
PF06337	DUSP domain DUSP	EX DUF	UNSCORED	Not scored	14,872	14	10,453	not covered by the cross-Mech scan	SEEDED
PF07366	SnoaL-like polyketide cyclase SnoaL	EX DUF	UNSCORED	Not scored	14,779	19	9,298	not covered by the cross-Mech scan	SEEDED
PF02616	Segregation and condensation protein ScpA SMC_ScpA	EX DUF	UNSCORED	Not scored	14,767	7	9,617	not covered by the cross-Mech scan	SEEDED
PF04313	Type I restriction enzyme R protein N terminus (HSDR_N) HSDR_N	EX DUF	UNSCORED	Not scored	14,720	11	9,590	not covered by the cross-Mech scan	SEEDED
PF17384	RimP C-terminal Sm-like domain RimP_C	EX DUF	UNSCORED	Not scored	14,671	13	9,640	not covered by the cross-Mech scan	SEEDED
PF02622	AlgH-like DUF179	KNOWN HISTORICAL DUF	UNSCORED	Not scored	14,657	8	9,886	ProteinTraitsMech: 4; ProteinTraitsMech trait record	SEEDED
PF01904	Protein of unknown function DUF72 DUF72	UNKNOWN CANDIDATE	UNSCORED	Not scored	14,646	3	8,861	ProteinTraitsMech: 4; ProteinTraitsMech trait record	SEEDED
PF02696	Protein adenylyltransferase SelO SelO	EX DUF	UNSCORED	Not scored	14,609	8	10,025	not covered by the cross-Mech scan	SEEDED
PF04307	YdjM inner membrane protein YdjM	EX DUF	UNSCORED	Not scored	14,526	0	9,793	not covered by the cross-Mech scan	SEEDED
PF04727	ELMO/CED-12 family ELMO_CED12	EX DUF	UNSCORED	Not scored	14,425	15	12,473	not covered by the cross-Mech scan	SEEDED
PF07336	Putative stress-induced transcription regulator ABATE	EX DUF	UNSCORED	Not scored	14,367	1	7,669	not covered by the cross-Mech scan	SEEDED
PF02381	MraZ protein, putative antitoxin-like MraZ	EX DUF	UNSCORED	Not scored	14,311	8	9,623	not covered by the cross-Mech scan	SEEDED

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.