DUFMech families

Families

Download the complete family index (JSON)

8,296 of 8,296 families. Page 3 of 166.

Pfam	Family	Seed status	Characterization	Evidence counts	Proteins	Structures	AlphaFold	Other Mechs	Curation status
PF01128	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase IspD	EX DUF	UNSCORED	Not scored	19,574	56	13,015	not covered by the cross-Mech scan	SEEDED
PF04452	RNA methyltransferase domain Methyltrans_RNA	EX DUF	UNSCORED	Not scored	19,573	16	12,672	not covered by the cross-Mech scan	SEEDED
PF03195	Lateral organ boundaries (LOB) domain LOB	EX DUF	UNSCORED	Not scored	19,543	1	15,891	not covered by the cross-Mech scan	SEEDED
PF06439	3-keto-alpha-glucoside-1,2-lyase-like domain 3keto-disac_hyd	EX DUF	UNSCORED	Not scored	19,525	18	12,269	not covered by the cross-Mech scan	SEEDED
PF02583	Metal-sensitive transcriptional repressor Trns_repr_metal	EX DUF	UNSCORED	Not scored	19,403	12	12,146	not covered by the cross-Mech scan	SEEDED
PF02580	D-Tyr-tRNA(Tyr) deacylase Tyr_Deacylase	EX DUF	UNSCORED	Not scored	19,377	22	13,734	not covered by the cross-Mech scan	SEEDED
PF03652	Holliday junction resolvase RuvX	EX DUF	UNSCORED	Not scored	19,330	7	12,884	not covered by the cross-Mech scan	SEEDED
PF04002	RadC-like JAB domain RadC	EX DUF	UNSCORED	Not scored	19,203	1	12,619	not covered by the cross-Mech scan	SEEDED
PF03479	Plants and Prokaryotes Conserved (PCC) domain PCC	EX DUF	UNSCORED	Not scored	19,177	7	15,108	not covered by the cross-Mech scan	SEEDED
PF03976	Polyphosphate kinase 2 (PPK2) PPK2	EX DUF	UNSCORED	Not scored	18,956	33	12,011	not covered by the cross-Mech scan	SEEDED
PF00902	Sec-independent protein translocase protein (TatC) TatC	EX DUF	UNSCORED	Not scored	18,890	11	12,534	not covered by the cross-Mech scan	SEEDED
PF02588	Uncharacterised 5xTM membrane BCR, YitT family COG1284 YitT_membrane	EX DUF	UNSCORED	Not scored	18,836	0	12,122	not covered by the cross-Mech scan	SEEDED
PF07589	PEP-CTERM protein-sorting motif PEP_exosort_dom	EX DUF	UNSCORED	Not scored	18,700	0	12,061	not covered by the cross-Mech scan	SEEDED
PF19296	RelA/SpoT AH domain RelA_AH	EX DUF	UNSCORED	Not scored	18,698	9	11,911	not covered by the cross-Mech scan	SEEDED
PF02656	Domain of unknown function (DUF202) DUF202	UNKNOWN CANDIDATE	UNSCORED	Not scored	18,669	3	13,291	ProteinTraitsMech: 18; ProteinTraitsMech trait record	SEEDED
PF13340	Putative transposase of IS4/5 family (DUF4096) DUF4096	KNOWN HISTORICAL DUF	UNSCORED	Not scored	18,629	0	11,006	ProteinTraitsMech: 1; ProteinTraitsMech trait record	SEEDED
PF01205	Impact N-terminal domain Impact_N	EX DUF	UNSCORED	Not scored	18,592	5	12,878	not covered by the cross-Mech scan	SEEDED
PF01988	VIT family VIT1	EX DUF	UNSCORED	Not scored	18,585	6	13,084	not covered by the cross-Mech scan	SEEDED
PF01784	Duf34/NIF3 (NGG1p interacting factor 3) DUF34_NIF3	KNOWN HISTORICAL DUF	UNSCORED	Not scored	18,574	16	12,676	ProteinTraitsMech: 6; ProteinTraitsMech trait record	SEEDED
PF02720	Domain of unknown function (DUF222) DUF222	UNKNOWN CANDIDATE	UNSCORED	Not scored	18,467	0	11,207	ProteinTraitsMech: 1; ProteinTraitsMech trait record	SEEDED
PF01206	Sulfurtransferase TusA TusA	EX DUF	UNSCORED	Not scored	18,434	9	12,368	not covered by the cross-Mech scan	SEEDED
PF01970	Tripartite tricarboxylate transporter TctA family TctA	EX DUF	UNSCORED	Not scored	18,234	0	11,882	not covered by the cross-Mech scan	SEEDED
PF08818	Domain of unknown function (DU1801) DUF1801	UNKNOWN CANDIDATE	UNSCORED	Not scored	18,172	4	11,286	ProteinTraitsMech: 4; ProteinTraitsMech trait record	SEEDED
PF01987	Mitochondrial biogenesis AIM24 AIM24	EX DUF	UNSCORED	Not scored	18,102	2	11,118	not covered by the cross-Mech scan	SEEDED
PF02618	YceG-like family YceG	EX DUF	UNSCORED	Not scored	18,081	4	11,324	not covered by the cross-Mech scan	SEEDED
PF02367	Threonylcarbamoyl adenosine biosynthesis protein TsaE TsaE	EX DUF	UNSCORED	Not scored	17,972	8	11,648	not covered by the cross-Mech scan	SEEDED
PF09995	ER-bound oxygenase mpaB/B'/Rubber oxygenase, catalytic domain MPAB_Lcp_cat	EX DUF	UNSCORED	Not scored	17,931	2	10,982	not covered by the cross-Mech scan	SEEDED
PF04749	PLAC8 family PLAC8	EX DUF	UNSCORED	Not scored	17,863	0	14,963	not covered by the cross-Mech scan	SEEDED
PF08742	C8 domain C8	EX DUF	UNSCORED	Not scored	17,796	36	8,017	not covered by the cross-Mech scan	SEEDED
PF04535	Casparian strip membrane protein domain CASP_dom	EX DUF	UNSCORED	Not scored	17,754	0	14,486	not covered by the cross-Mech scan	SEEDED
PF04515	Plasma-membrane choline transporter Choline_transpo	EX DUF	UNSCORED	Not scored	17,743	3	15,287	not covered by the cross-Mech scan	SEEDED
PF13356	Arm DNA-binding domain Arm-DNA-bind_3	EX DUF	UNSCORED	Not scored	17,731	3	11,201	not covered by the cross-Mech scan	SEEDED
PF03141	Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_29	EX DUF	UNSCORED	Not scored	17,659	0	14,289	not covered by the cross-Mech scan	SEEDED
PF06292	MUN domain MUN	EX DUF	UNSCORED	Not scored	17,631	12	6,555	not covered by the cross-Mech scan	SEEDED
PF02625	XdhC and CoxI family XdhC_CoxI	EX DUF	UNSCORED	Not scored	17,613	3	10,616	not covered by the cross-Mech scan	SEEDED
PF06283	Trehalose utilisation ThuA	EX DUF	UNSCORED	Not scored	17,609	4	10,006	not covered by the cross-Mech scan	SEEDED
PF05598	Transposase domain (DUF772) DUF772	KNOWN HISTORICAL DUF	UNSCORED	Not scored	17,572	0	11,560	ProteinTraitsMech: 7; ProteinTraitsMech trait record	SEEDED
PF04672	S-adenosyl methyltransferase Methyltransf_19	EX DUF	UNSCORED	Not scored	17,491	3	9,288	not covered by the cross-Mech scan	SEEDED
PF04536	TPM domain TPM_phosphatase	EX DUF	UNSCORED	Not scored	17,406	12	11,136	not covered by the cross-Mech scan	SEEDED
PF02620	Large ribosomal RNA subunit accumulation protein YceD YceD	EX DUF	UNSCORED	Not scored	17,397	0	11,341	not covered by the cross-Mech scan	SEEDED
PF01809	Putative membrane protein insertion efficiency factor YidD	EX DUF	UNSCORED	Not scored	17,388	0	11,202	not covered by the cross-Mech scan	SEEDED
PF02576	RimP N-terminal domain RimP_N	EX DUF	UNSCORED	Not scored	17,354	13	11,476	not covered by the cross-Mech scan	SEEDED
PF20152	Family of unknown function (DUF6534) DUF6534	UNKNOWN CANDIDATE	UNSCORED	Not scored	17,299	0	14,906	ProteinTraitsMech trait record	SEEDED
PF04237	YjbR YjbR	EX DUF	UNSCORED	Not scored	17,203	4	10,217	not covered by the cross-Mech scan	SEEDED
PF02699	Preprotein translocase subunit YajC	EX DUF	UNSCORED	Not scored	17,195	1	11,325	not covered by the cross-Mech scan	SEEDED
PF03928	Haem degrading protein HbpS-like HbpS-like	EX DUF	UNSCORED	Not scored	17,179	10	10,836	not covered by the cross-Mech scan	SEEDED
PF04978	Mycothiol-S-transferase MST	EX DUF	UNSCORED	Not scored	16,967	3	9,298	not covered by the cross-Mech scan	SEEDED
PF06224	DNA glycosylase AlkZ-like AlkZ-like	EX DUF	UNSCORED	Not scored	16,955	2	9,642	not covered by the cross-Mech scan	SEEDED
PF20239	Family of unknown function (DUF6596) DUF6596	UNKNOWN CANDIDATE	UNSCORED	Not scored	16,812	0	9,780	ProteinTraitsMech: 1; ProteinTraitsMech trait record	SEEDED
PF04402	Protein of unknown function (DUF541) SIMPL	EX DUF	UNSCORED	Not scored	16,767	3	10,934	ProteinTraitsMech: 4; ProteinTraitsMech trait record	SEEDED

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.