DUFMech families

Families

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8,296 of 8,296 families. Page 2 of 166.

Pfam	Family	Seed status	Characterization	Evidence counts	Proteins	Structures	AlphaFold	Other Mechs	Curation status
PF03478	KIB1-4 beta-propeller Beta-prop_KIB1-4	EX DUF	UNSCORED	Not scored	29,927	0	24,983	not covered by the cross-Mech scan	SEEDED
PF00893	Small Multidrug Resistance protein Multi_Drug_Res	EX DUF	UNSCORED	Not scored	28,663	20	17,571	not covered by the cross-Mech scan	SEEDED
PF01657	Salt stress response/antifungal Stress-antifung	EX DUF	UNSCORED	Not scored	28,393	4	22,295	not covered by the cross-Mech scan	SEEDED
PF01027	Inhibitor of apoptosis-promoting Bax1 Bax1-I	EX DUF	UNSCORED	Not scored	27,980	9	21,884	not covered by the cross-Mech scan	SEEDED
PF05970	PIF1-like helicase PIF1	EX DUF	UNSCORED	Not scored	26,740	37	18,182	not covered by the cross-Mech scan	SEEDED
PF02405	Permease MlaE MlaE	EX DUF	UNSCORED	Not scored	26,408	22	17,443	not covered by the cross-Mech scan	SEEDED
PF11887	Cholesterol uptake porter CUP1 of Mce4, putative Mce4_CUP1	EX DUF	UNSCORED	Not scored	25,778	3	16,154	not covered by the cross-Mech scan	SEEDED
PF06722	Erythromycin biosynthesis protein CIII-like, C-terminal domain EryCIII-like_C	EX DUF	UNSCORED	Not scored	25,744	57	15,860	not covered by the cross-Mech scan	SEEDED
PF04818	CID domain CID	EX DUF	UNSCORED	Not scored	25,708	42	18,538	not covered by the cross-Mech scan	SEEDED
PF02698	DUF218 domain DUF218	KNOWN HISTORICAL DUF	UNSCORED	Not scored	25,685	1	15,881	ProteinTraitsMech: 7; ProteinTraitsMech trait record	SEEDED
PF01936	NYN domain NYN	EX DUF	UNSCORED	Not scored	25,419	3	16,110	not covered by the cross-Mech scan	SEEDED
PF01895	PhoU domain PhoU	EX DUF	UNSCORED	Not scored	24,850	10	16,970	not covered by the cross-Mech scan	SEEDED
PF02575	YbaB/EbfC DNA-binding family YbaB_DNA_bd	EX DUF	UNSCORED	Not scored	24,833	5	16,239	not covered by the cross-Mech scan	SEEDED
PF01909	Nucleotidyltransferase domain NTP_transf_2	EX DUF	UNSCORED	Not scored	24,660	133	16,552	not covered by the cross-Mech scan	SEEDED
PF07734	F-box associated beta propeller domain FBA_1	EX DUF	UNSCORED	Not scored	24,373	0	18,568	not covered by the cross-Mech scan	SEEDED
PF04547	Calcium-activated chloride channel Anoctamin	EX DUF	UNSCORED	Not scored	24,367	78	20,769	not covered by the cross-Mech scan	SEEDED
PF06071	Protein of unknown function (DUF933) YchF-GTPase_C	EX DUF	UNSCORED	Not scored	23,701	12	16,566	ProteinTraitsMech trait record	SEEDED
PF14111	Domain of unknown function (DUF4283) DUF4283	UNKNOWN CANDIDATE	UNSCORED	Not scored	23,437	0	17,164	ProteinTraitsMech trait record	SEEDED
PF01121	Dephospho-CoA kinase CoaE	EX DUF	UNSCORED	Not scored	23,389	26	16,271	not covered by the cross-Mech scan	SEEDED
PF03706	Lysylphosphatidylglycerol synthase TM region LPG_synthase_TM	EX DUF	UNSCORED	Not scored	23,174	6	14,907	not covered by the cross-Mech scan	SEEDED
PF01709	TACO1/YebC second and third domain Transcrip_reg	EX DUF	UNSCORED	Not scored	23,092	12	15,841	not covered by the cross-Mech scan	SEEDED
PF03703	Bacterial PH domain bPH_2	EX DUF	UNSCORED	Not scored	23,024	0	14,560	not covered by the cross-Mech scan	SEEDED
PF02604	Antitoxin Phd_YefM, type II toxin-antitoxin system PhdYeFM_antitox	EX DUF	UNSCORED	Not scored	22,715	24	14,574	not covered by the cross-Mech scan	SEEDED
PF01256	NAD(P)H-hydrate dehydratase Carb_kinase	EX DUF	UNSCORED	Not scored	22,302	37	15,274	not covered by the cross-Mech scan	SEEDED
PF16344	FecR, C-terminal FecR_C	EX DUF	UNSCORED	Not scored	22,280	2	14,798	not covered by the cross-Mech scan	SEEDED
PF14291	ZMYM1/FAM200, RNase-like domain DUF4371	KNOWN HISTORICAL DUF	UNSCORED	Not scored	21,818	0	15,479	ProteinTraitsMech: 5; ProteinTraitsMech trait record	SEEDED
PF03929	PepSY-associated TM region PepSY_TM	EX DUF	UNSCORED	Not scored	21,711	1	12,939	not covered by the cross-Mech scan	SEEDED
PF03140	Plant protein of unknown function DUF247	UNKNOWN CANDIDATE	UNSCORED	Not scored	21,663	0	17,072	ProteinTraitsMech: 1; ProteinTraitsMech trait record	SEEDED
PF02714	Calcium-dependent channel, 7TM region, putative phosphate RSN1_7TM	EX DUF	UNSCORED	Not scored	21,614	41	17,197	not covered by the cross-Mech scan	SEEDED
PF08699	Argonaute linker 1 domain ArgoL1	EX DUF	UNSCORED	Not scored	21,447	74	18,036	not covered by the cross-Mech scan	SEEDED
PF05653	Magnesium transporter NIPA Mg_trans_NIPA	EX DUF	UNSCORED	Not scored	21,330	0	17,719	not covered by the cross-Mech scan	SEEDED
PF05050	Methyltransferase FkbM domain Methyltransf_21	EX DUF	UNSCORED	Not scored	21,317	1	14,912	not covered by the cross-Mech scan	SEEDED
PF06114	IrrE N-terminal-like domain Peptidase_M78	EX DUF	UNSCORED	Not scored	21,240	10	13,293	not covered by the cross-Mech scan	SEEDED
PF02410	Ribosomal silencing factor during starvation RsfS	EX DUF	UNSCORED	Not scored	21,229	56	14,690	not covered by the cross-Mech scan	SEEDED
PF01795	MraW methylase family Methyltransf_5	EX DUF	UNSCORED	Not scored	21,149	20	14,300	not covered by the cross-Mech scan	SEEDED
PF01493	GXGXG motif GXGXG	EX DUF	UNSCORED	Not scored	21,023	13	1,560	not covered by the cross-Mech scan	SEEDED
PF03564	Protein of unknown function (DUF1759) DUF1759	UNKNOWN CANDIDATE	UNSCORED	Not scored	20,944	0	12,110	ProteinTraitsMech trait record	SEEDED
PF13732	ATP-binding protein DrrA1-3-like, C-terminal domain DrrA1-3_C	EX DUF	UNSCORED	Not scored	20,925	5	13,059	not covered by the cross-Mech scan	SEEDED
PF14534	Domain of unknown function (DUF4440) DUF4440	UNKNOWN CANDIDATE	UNSCORED	Not scored	20,901	14	13,058	ProteinTraitsMech trait record	SEEDED
PF14703	Cytosolic domain of 10TM putative phosphate transporter PHM7_cyt	EX DUF	UNSCORED	Not scored	20,870	41	16,802	not covered by the cross-Mech scan	SEEDED
PF04893	Yip1 domain Yip1	EX DUF	UNSCORED	Not scored	20,702	0	16,138	not covered by the cross-Mech scan	SEEDED
PF18701	Family of unknown function (DUF5641) DUF5641	UNKNOWN CANDIDATE	UNSCORED	Not scored	20,636	0	11,735	ProteinTraitsMech trait record	SEEDED
PF10282	Lactonase, 7-bladed beta-propeller Lactonase	EX DUF	UNSCORED	Not scored	20,552	10	13,530	not covered by the cross-Mech scan	SEEDED
PF02637	GatB domain GatB_Yqey	EX DUF	UNSCORED	Not scored	20,276	15	14,437	not covered by the cross-Mech scan	SEEDED
PF03193	RsgA GTPase RsgA_GTPase	EX DUF	UNSCORED	Not scored	20,259	17	12,792	not covered by the cross-Mech scan	SEEDED
PF02586	SOS response associated peptidase (SRAP) SRAP	EX DUF	UNSCORED	Not scored	20,212	19	13,289	not covered by the cross-Mech scan	SEEDED
PF02130	Endoribonuclease YbeY YbeY	EX DUF	UNSCORED	Not scored	20,178	5	13,642	not covered by the cross-Mech scan	SEEDED
PF02589	LUD domain LUD_dom	EX DUF	UNSCORED	Not scored	19,968	1	12,910	not covered by the cross-Mech scan	SEEDED
PF03692	Putative zinc- or iron-chelating domain CxxCxxCC	EX DUF	UNSCORED	Not scored	19,814	0	13,049	not covered by the cross-Mech scan	SEEDED
PF02617	ATP-dependent Clp protease adaptor protein ClpS ClpS	EX DUF	UNSCORED	Not scored	19,694	39	10,649	not covered by the cross-Mech scan	SEEDED

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.