DUFMech families

Families

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8,296 of 8,296 families. Page 5 of 166.

Pfam	Family	Seed status	Characterization	Evidence counts	Proteins	Structures	AlphaFold	Other Mechs	Curation status
PF20151	Family of unknown function (DUF6533) DUF6533	UNKNOWN CANDIDATE	UNSCORED	Not scored	14,207	0	12,310	ProteinTraitsMech trait record	SEEDED
PF01933	2-phospho-L-lactate transferase CofD CofD	EX DUF	UNSCORED	Not scored	14,174	13	9,318	not covered by the cross-Mech scan	SEEDED
PF01894	UPF0047 protein YjbQ-like YjbQ	EX DUF	UNSCORED	Not scored	14,125	9	9,964	not covered by the cross-Mech scan	SEEDED
PF03235	GmrSD restriction endonuclease, N-terminal domain GmrSD_N	EX DUF	UNSCORED	Not scored	14,123	8	9,036	TaxonMech: 1; TraitMech: 1; not covered by the cross-Mech scan	SEEDED
PF04239	YetF C-terminal domain DUF421	KNOWN HISTORICAL DUF	UNSCORED	Not scored	14,102	1	8,907	ProteinTraitsMech: 6; ProteinTraitsMech trait record	SEEDED
PF09851	Short C-terminal domain SHOCT	EX DUF	UNSCORED	Not scored	14,053	0	8,874	not covered by the cross-Mech scan	SEEDED
PF02590	Predicted SPOUT methyltransferase SPOUT_MTase	EX DUF	UNSCORED	Not scored	13,939	11	9,472	not covered by the cross-Mech scan	SEEDED
PF11807	Mycotoxin biosynthesis protein UstYa UstYa	EX DUF	UNSCORED	Not scored	13,931	0	11,959	not covered by the cross-Mech scan	SEEDED
PF03780	Asp23 family, cell envelope-related function Asp23	EX DUF	UNSCORED	Not scored	13,917	0	8,818	not covered by the cross-Mech scan	SEEDED
PF05903	PPPDE putative peptidase domain Peptidase_C97	EX DUF	UNSCORED	Not scored	13,767	2	11,440	not covered by the cross-Mech scan	SEEDED
PF02636	Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_28	EX DUF	UNSCORED	Not scored	13,694	6	10,000	not covered by the cross-Mech scan	SEEDED
PF05916	GINS complex protein helical bundle domain Sld5	EX DUF	UNSCORED	Not scored	13,691	51	11,723	not covered by the cross-Mech scan	SEEDED
PF04258	Signal peptide peptidase Peptidase_A22B	EX DUF	UNSCORED	Not scored	13,660	2	11,659	not covered by the cross-Mech scan	SEEDED
PF02660	Glycerol-3-phosphate acyltransferase G3P_acyltransf	EX DUF	UNSCORED	Not scored	13,599	6	9,067	not covered by the cross-Mech scan	SEEDED
PF19291	Trehalase-like, N-terminal TREH_N	EX DUF	UNSCORED	Not scored	13,539	0	8,077	not covered by the cross-Mech scan	SEEDED
PF06912	Protein of unknown function (DUF1275) DUF1275	UNKNOWN CANDIDATE	UNSCORED	Not scored	13,380	0	8,845	ProteinTraitsMech: 1; ProteinTraitsMech trait record	SEEDED
PF01169	Divalent cation/proton antiporter GDT1 GDT1	EX DUF	UNSCORED	Not scored	13,378	0	9,762	not covered by the cross-Mech scan	SEEDED
PF02016	LD-carboxypeptidase N-terminal domain Peptidase_S66	EX DUF	UNSCORED	Not scored	13,359	37	8,109	not covered by the cross-Mech scan	SEEDED
PF03668	RapZ-like N-terminal domain RapZ-like_N	EX DUF	UNSCORED	Not scored	13,324	6	8,655	not covered by the cross-Mech scan	SEEDED
PF05553	Cotton fibre expressed protein DUF761	UNKNOWN CANDIDATE	UNSCORED	Not scored	13,240	0	10,797	ProteinTraitsMech: 3; ProteinTraitsMech trait record	SEEDED
PF07510	GmrSD restriction endonucleases, C-terminal domain GmrSD_C	EX DUF	UNSCORED	Not scored	13,168	7	7,977	not covered by the cross-Mech scan	SEEDED
PF12769	4TM region of pyridine nucleotide transhydrogenase, mitoch PNTB_4TM	EX DUF	UNSCORED	Not scored	13,121	14	9,222	not covered by the cross-Mech scan	SEEDED
PF05670	NFACT protein RNA binding domain NFACT-R_1	EX DUF	UNSCORED	Not scored	13,115	20	10,207	not covered by the cross-Mech scan	SEEDED
PF06738	Putative threonine/serine exporter ThrE	EX DUF	UNSCORED	Not scored	13,070	0	8,741	not covered by the cross-Mech scan	SEEDED
PF13491	4TM region of DNA translocase FtsK/SpoIIIE FtsK_4TM	EX DUF	UNSCORED	Not scored	13,056	0	8,415	not covered by the cross-Mech scan	SEEDED
PF16016	VAD1 Analog of StAR-related lipid transfer domain VASt	EX DUF	UNSCORED	Not scored	12,938	12	9,903	not covered by the cross-Mech scan	SEEDED
PF04326	Schlafen, AlbA_2 SLFN_AlbA_2	EX DUF	UNSCORED	Not scored	12,925	31	8,752	not covered by the cross-Mech scan	SEEDED
PF01549	ShK domain-like ShK	EX DUF	UNSCORED	Not scored	12,913	10	11,217	not covered by the cross-Mech scan	SEEDED
PF12130	Bivalent Mical/EHBP Rab binding domain bMERB_dom	EX DUF	UNSCORED	Not scored	12,866	14	7,449	not covered by the cross-Mech scan	SEEDED
PF13102	Phage integrase SAM-like domain Phage_int_SAM_5	EX DUF	UNSCORED	Not scored	12,837	1	8,564	not covered by the cross-Mech scan	SEEDED
PF05258	Dna[CI] antecedent, DciA DciA	EX DUF	UNSCORED	Not scored	12,811	2	8,175	not covered by the cross-Mech scan	SEEDED
PF02996	Prefoldin subunit Prefoldin	EX DUF	UNSCORED	Not scored	12,752	9	10,916	not covered by the cross-Mech scan	SEEDED
PF14309	LONGIFOLIA 1/2-like C-terminal domain DUF4378	KNOWN HISTORICAL DUF	UNSCORED	Not scored	12,694	0	9,735	ProteinTraitsMech: 5; ProteinTraitsMech trait record	SEEDED
PF04134	DCC1-like thiol-disulfide oxidoreductase DCC1-like	EX DUF	UNSCORED	Not scored	12,691	0	8,314	not covered by the cross-Mech scan	SEEDED
PF07332	Putative Actinobacterial Holin-X, holin superfamily III Phage_holin_3_6	EX DUF	UNSCORED	Not scored	12,683	0	7,594	not covered by the cross-Mech scan	SEEDED
PF01697	Glycosyltransferase family 92 Glyco_transf_92	EX DUF	UNSCORED	Not scored	12,672	2	10,516	not covered by the cross-Mech scan	SEEDED
PF04480	Protein of unknown function (DUF559) DUF559	UNKNOWN CANDIDATE	UNSCORED	Not scored	12,664	2	7,682	ProteinTraitsMech: 6; ProteinTraitsMech trait record	SEEDED
PF04784	Protein of unknown function, DUF547 DUF547	UNKNOWN CANDIDATE	UNSCORED	Not scored	12,661	0	9,535	ProteinTraitsMech trait record	SEEDED
PF01139	tRNA-splicing ligase RtcB RtcB	EX DUF	UNSCORED	Not scored	12,598	20	8,370	not covered by the cross-Mech scan	SEEDED
PF02595	Glycerate kinase family Gly_kinase	EX DUF	UNSCORED	Not scored	12,566	2	7,697	not covered by the cross-Mech scan	SEEDED
PF01345	CLIPPER domain CLIPPER	EX DUF	UNSCORED	Not scored	12,543	1	5,072	not covered by the cross-Mech scan	SEEDED
PF09994	T6SS, Phospholipase effector Tle1-like, catalytic domain T6SS_Tle1-like_cat	EX DUF	UNSCORED	Not scored	12,473	4	9,172	not covered by the cross-Mech scan	SEEDED
PF07970	Endoplasmic reticulum vesicle transporter COPIIcoated_ERV	EX DUF	UNSCORED	Not scored	12,470	1	10,681	not covered by the cross-Mech scan	SEEDED
PF07944	Beta-L-arabinofuranosidase, GH127 catalytic domain Beta-AFase-like_GH127_cat	EX DUF	UNSCORED	Not scored	12,425	20	8,038	not covered by the cross-Mech scan	SEEDED
PF08044	DUF1707 SHOCT-like domain DUF1707	KNOWN HISTORICAL DUF	UNSCORED	Not scored	12,418	0	7,035	ProteinTraitsMech: 1; ProteinTraitsMech trait record	SEEDED
PF09324	Mon2/Sec7/BIG1-like, HDS Sec7-like_HDS	EX DUF	UNSCORED	Not scored	12,400	1	1,000	not covered by the cross-Mech scan	SEEDED
PF05787	Alkaline phosphatase PhoX PhoX	EX DUF	UNSCORED	Not scored	12,367	5	7,140	not covered by the cross-Mech scan	SEEDED
PF03959	Serine hydrolase (FSH1) FSH1	EX DUF	UNSCORED	Not scored	12,327	1	10,109	not covered by the cross-Mech scan	SEEDED
PF11835	RRM-like domain RRM_8	EX DUF	UNSCORED	Not scored	12,213	9	10,537	not covered by the cross-Mech scan	SEEDED
PF04398	Protein of unknown function, DUF538 DUF538	UNKNOWN CANDIDATE	UNSCORED	Not scored	12,176	1	10,110	ProteinTraitsMech: 3; ProteinTraitsMech trait record	SEEDED

Status and evidence

Seed status: A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization: A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts: Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status: Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts: Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.